Education, tips and tricks to help you conduct better fMRI experiments.
Sure, you can try to fix it during data processing, but you're usually better off fixing the acquisition!

Friday, February 9, 2024

Core curriculum - Mathematics: Linear algebra II


Continuing the series on linear algebra using the lectures from 3Blue1Brown, we are getting into some of the operations that will become mainstays of fMRI processing later on. It's entirely possible to do the processing steps in rote fashion as an fMRI practitioner, but understanding the foundations should help you recognize the limits of different approaches.


A4. Matrix multiplication as composition

In this video we see how to treat more than one transformation on a space, and how the order of transformations is important.

 



Q: While brains come in all shapes and sizes, we often seek to interpret neuroimaging results in some sort of "average brain" space, or template. We need to account for the variable position and size of anatomical structures. However, we also have the variability of where that brain was located in the scanner, e.g. because of different amounts and types of padding, operator error, and so on. When do you think it makes the most sense to correct for translations and rotations in the scanner: before or after trying to put individual brain anatomy into an "average brain" space? Or does it not matter?


 A5. Three-dimensional linear transformations

 Now we're going to move on from 2D to 3D spaces. Same basic rationale, just more numbers to track!

 


A6. The determinant 

 



A7. Inverse matrices, column space and null space

 


 

Perhaps it's not fully clear why we might need the inverse matrix. It turns out to be the way to achieve the equivalent of division using matrices. To galvanize this insight, let's look at the concept of an inverse matrix for solving an equation without division. Leaving aside the slightly goofy intro, it's a useful tutorial on the mechanics of determining an inverse matrix. 



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